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210. basic math is your friend.

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Q: I am thinking of a three-diget number If you subtract 5 from it the restult is divisible by 5 If you subtract 6 from it the restult is divisible by 6 if you subtract 7 f?
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Is the intranasal flu vaccine more effective than flu vaccines administered with a needle?

The answer to this depends greatly on some widely differing variables. Patient age, health status and how well the vaccine used in the trials matched the viruses circulating at the time of the study are three of the most significant influences on the trial results making comparisons difficult.The US Centers for Disease Control and Prevention's (CDC) bottom line best estimate from studies is that, for healthy children, the intranasal flu vaccine made with the live attenuated (weakened) influenza virus (LAIV) is more effective in offering protection against the flu than the injected vaccines (the LAIV intranasal vaccine is recommended only for healthy people age 2 - 49), although there is not a huge difference.For healthy children receiving live vaccine: efficacy was 86% overall. In one large study among children aged 15-85 months, the seasonal nasal-spray flu vaccine (LAIV) reduced the chance of influenza illness by 92% compared with placebo, but the match of the vaccine virus to the viruses in the wild was better during that trial period compared to the study with the efficacy results of 86%, too, which makes comparison more difficult.For healthy adults under age 65, the studies mostly indicate that there is no statistical difference in effectiveness between receipt of live flu vaccines or inactivated vaccines. However specific studies of healthy college age adults suggested that inactivated vaccine may be more efficacious than live vaccine for this age group. The overall efficacy of LAIV and inactivated influenza vaccine in preventing laboratory-documented influenza from all three influenza strains combined was 85% for LAIV and 71% for inactivated injected vaccines.In older trial participants aged 65 and over, the effectiveness of flu vaccines is generally overall lower (efficacy of 58%), but since this group also usually has more underlying health issues and may be more susceptible and more prone to complications and death (the majority of the estimated 36,000 deaths from seasonal flu each year in the US are among this older age group), that is not easily assessed. There are some flu vaccines made especially for this age group that give a stronger dose to help improve effectiveness.The studies were also difficult for this > 65 age group because those who reside in long term care (LTC) facilities are typically more susceptible and have more incidence of transmission of flu viruses from staff, visitors, and other residents. Therefore, the immunization against flu in this LTC subgroup can significantly reduce infection rates and is highly recommended since this group has the highest morbidity and mortality rates from the flu. And these variables can also skew the statistics in trials, making estimates of the difference between the effectiveness very difficult to impossible to provide.See the links below in the Related Links section to the CDC site for more specific details.More information:Flu vaccines have a relatively similar effectiveness regardless of the route of administration or regardless if it is LAIV vs. an inactivated vaccine within specific groups, but the effectiveness varies between the groups.Those vaccines administered with needles are made with inactivated virus particles which can make a weaker immune response, while the intranasal vaccine for the flu is made with LAIV (Live Attenuated Influenza Viruses) that are treated so that they can not make an otherwise healthy person sick with the flu, but trigger a stronger response.The immune response to an inactivated virus is less robust than that to the live weakened virus. However, the injected route can produce a more immediate and robust response compared to the less invasive, slightly slower acting intranasal route. So, the end restult is relatively the same in a general evaluation.