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Negative chronotropes are substances or factors that decrease heart rate. Examples include medications such as beta-blockers (e.g., metoprolol) and calcium channel blockers (e.g., verapamil), which are often used to manage conditions like hypertension and arrhythmias. Other examples include increased levels of the hormone acetylcholine, which can slow heart rate by acting on the parasympathetic nervous system. Additionally, certain medical conditions, such as high vagal tone or myocardial infarction, can also act as negative chronotropes.

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3d ago

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