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Is nonpyrogenic and sterile the same thing?
No, nonpyrogenic and sterile are not the same. "Nonpyrogenic" refers to a product or substance that does not produce fever-inducing substances (pyrogens), often related to bacterial contamination. "Sterile," on the other hand, means that the item is free from all viable microorganisms, including bacteria, viruses, and spores. While both terms are important in medical and pharmaceutical contexts, they address different aspects of product safety and cleanliness.
How do you make lactated ringers at home?
Lactated Ringer's is a sterile, nonpyrogenic solution containing isotonic concentrations of electrolytes in water for injection. Lactated Ringer's is administered by intravenous infusion for parenteral replacement of extracellular losses of fluid and electrolytes. Each 100 mL of Lactated Ringer's Injection, USP contains sodium chloride 600 mg, sodium lactate, anhydrous 310 mg, potassium chloride 30 mg and calcium chloride, dihydrate 20 mg. May contain hydrochloric acid and/or sodium hydroxide for pH adjustment. A liter provides 9 calories (from lactate), sodium (Na+), 130 mEq, potassium (K+) 4 mEq, calcium (Ca-++) 3 mEq, chloride (Cl-) 109 mEq and lactate [CH3CH(OH) COO-] 28 mEq. The electrolyte content is isotonic (273 mOsmol/liter, calc.) in relation to the extracellular fluid (approx. 280 mOsmol/liter). The pH of the solution is 6.6 (6.0-7.5). The solution contains no bacteriostat, antimicrobial agent or added buffer (except for pH adjustment) and each is intended only for use as a single-dose injection. When smaller doses are required the unused portion should be discarded.ctated Ringer's is a sterile, nonpyrogenic solution containing isotonic concentrations of electrolytes in water for injection. Lactated Ringer's is administered by intravenous infusion for parenteral replacement of extracellular losses of fluid and electrolytes.
