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43.

Alternatively add and subtract, doubling the amount each time, starting with 1:

0 + 1 = 1

1 - 2 = -1

-1 + 4 = 3

3 - 8 = -5

-5 + 16 = 11

11 - 32 = -21

So add 64 for the next term: -21 + 64 = 43

(The next term would then be subtract 128: 43 - 128 = -85)

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Q: What is the next number in the sequence 0 1 -1 3 -5 11 -21?
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