Intrinsic factor helps absorb Vitamin B12. Vitamin B12 is needed for hemoglobin production. Therefore, without IF, you would see a decrease in the number of RBC's.
"Intrisic factor" is necessary for B12 absorption
B12 is the vitamin that requires intrinsic factor for absorption. B12 is also known as cobalamin.
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Vitamin B12 can only be absorbed when it is attached to intrinsic factor
It is called intrinsic factor, which enables the absorption of B12. Intrinsic factor is found in the parietal cells (mucosa cells) of the stomach lining.
Pernicious anemia is due to a deficiency of a vitamin called intrinsic factor, which is normally produced by cells of the stomach. Intrinsic factor is required for the absorption of vitamin B12, so if intrinsic factor levels are insufficient, vitamin B12 will not be absorbed well. So administration of vitamin B12 will only help treat vitamin B12-deficiency anemia if vitamin B12 can be absorbed, and this can only happen if there are adequate levels of intrinsic factor to begin with. Patients with pernicious anemia do not have adequate intrinsic factor levels, so they will not be helped by vitamin B12 treatment since they can't absorb it well enough.
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Intrinsic factor or gastric intrinsic factor is a protein produced by the stomach. It is used to absorb vitamin B12 in the small intestine. When there is a deficiency of the Intrinsic factor, there is a deficiency in the absorption of B12 into the body and this leads to pernicious anemia.