In the Comics I would say it is Venom, but I don't know who it would be in videogames...
i believe that the strongest non-quest enemy is Umbra
spiderman said that it was VENOM!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!
the mustain
spiderman first got the black suit at the end of the secret wars number 8
A chicken THE STRONGEST ENEMY IN THE SERIES!
Omega Shenron.
some are saying the enemy in spiderman 4 will be the lizzard. and also there will definitely be a spidey 4. not for a while tho
Emerald Weapon
Of course its toxin! Toxin can pretty much take on spiderman, Venom, and Carnage at the same time and still win
Ancient dragon
Spiderman, Spiderman 2, Spiderman 3, and recently the Amazing Spiderman
krangs 120 ft. robot