Want this question answered?
Generally, a probit analysis would be used to calculate the Lc50 (median lethal concentration) in SPSS. Probit analysis is a statistical technique frequently used to calculate the concentration or dose that produces a particular response in a specified subset of the population. Here's a step-by-step guide on how to use SPSS for Lc50 analysis using probit analysis: Data Preparation Import the data Descriptive Statistics Probit Analysis Model Estimation LC50 Estimation We suggest if you need help with SPSS for assignment writing, We will suggest VBAanalytic. They will provide SPSS assignments with high-quality content at a fair price. You can enlist their assistance.
15 years old
1530 mg per kilogram bodyweight, when taken orally by a rat (test on humans would be unwise).
Dimensions: 45.75" Wide, 25.75" Deep, 43" High (Rack Removed), 51.25" (Rack Installed), 222 lbs. With Bench
The relationship between the degree of response of the organism and the quantity of the chemical always assumes a classic concentration-response form. the graphs represent the results of the tests in which groups of the organisms of the same species were exposed to various concentrations of a chemical for a specific length of time.
Hazard Class 6 contains poisonous materials (6.1) and infectious agents (6.2). Division 6.1: Poisonous material is a material, other than a gas, which is known to be so toxic to humans as to afford a hazard to health during transportation, or which, in the absence of adequate data on human toxicity:Is presumed to be toxic to humans because it falls within any one of the following categories when tested on laboratory animals (whenever possible, animal test data that has been reported in the chemical literature should be used):Oral Toxicity: A liquid with an LD50 for acute oral toxicity of not more than 500 mg/kg or a solid with an LD50 for acute oral toxicity of not more than 200 mg/kg.Dermal Toxicity. A material with an LD50 for acute dermal toxicity of not more than 1000 mg/kg.Inhalation Toxicity: A dust or mist with an LC50 for acute toxicity on inhalation of not more than 10 mg/L; or a material with a saturated vapor concentration in air at 20 °C (68 °F) of more than one-fifth of the LC50 for acute toxicity on inhalation of vapors and with an LC50 for acute toxicity on inhalation of vapors of not more than 5000 ml/m³; or
The relationship between the degree of response of the organisms and the quantity of the chemical always assumes a classic concentration-response form. The graphs represent the results of tests in which groups of the organisms of the same species were exposed to various concentrations of a chemical for a specific length of time. The least variability in the curve is at the 50% level of response. The concentration at which 50% level of the individuals react after a specified length of exposure is used as a measure of the activity or toxicity of the chemical agent. In determining the relative toxicity of a new chemical to aquatic organisms, an acute toxicity test is first conducted to estimate the median lethal concentration of the chemical in the water to which test organisms are exposed. LC50 is the concentration estimated to produce mortality in 50% of a test population over a specific time period.
Lead is a cumulative poison, meaning it builds up in your system. The more often you have contact with it, the more precautions you should take. If you handle it often, it's important that you obtain and use good protection. As always, when in doubt, exercise increased caution. My greatest concern is human well being!
YES they do. Its disgraceful.It depends on the test. Everyone complains about the Draize test, which is the one where they hold open rabbits' eyes and drip chemicals in them. The one that's worse is the LD50 test. This determines the "acute toxicity" of a substance--LD50 means the dose that kills half the animals who receive it. They can do a skin contact LD50, an oral LD50, an inhalation LD50 (more correctly LC50--inhaled chemicals are rated in parts per million in air) or an injection LD50. If you are doing an oral LD50 on antifreeze, you squirt a measured dose of antifreeze down the throats of 100 animals--anything from mice to dogs are used. You then count the number of animals that die over the next 14 days. At the end you euthanize the ones who are still alive. If 50 or more of the animals died from antifreeze, you record the dose as the LD50 and you're done. If fewer than 50 die, you repeat the test with a new batch of animals and a higher dose. Antifreeze kills by destroying the kidneys, and there are even worse chemicals than that--imagine having to run an inhalation LC50 on nerve gas!
four new curcurmin analogs (compounds 1, 2, 17 and 18) were synthesized. 17 [3,5-bis(4-hydroxy-3-methoxy-5-methylcinnamyl)N-methylpiperidone] showed high activity with GI50, TGI, and LC50 MG-MID values of 21.3, 70.7, and 97.7 microM, respectively. 18 [3,5-bis(4-hydroxy-3-methoxy-5-methylcinnamyl)-N-ethylpiperidone] showed the highest activity in this study with GI50, TGI, LC50 MG-MID values of 4.4, 33.8, 89.1 microM, respectively. 18 is even more active than curcumin with GI50, TGI, LC50 MG-MID values of 38.4, 35.6, 66.0 microM; respectively. 8 showed moderate selectivity towards Leukemia cell line-subpanel with a ratio of 5.6 (curcumin ratio: 1.2 for the same subpanel). The in vitro anti-tumor screening reveals that the results go hand in hand with the in vitro free radical scavenging effects. The antioxidant effect of these compounds depends mainly on the stabilization of the formed phenoxy free radical for which the p-hydroxy phenyl moiety is essential. o-substitution by electron-donating groups like the o-methoxy group (and to a even higher degree by the ethoxy group) increases the stability of phenoxy free radical, hence increasing both free scavenging and anti-tumor effects. Increasing the alkyl group chain on the N in the series of substituted N-alkyl piperidones as well as the extension of conjugation, increases the stabilization of phenoxy free radical and thereby the activity towards both free radical scavenging and anti-tumor effects. This may be attributed to an increased positive inductive effect and/or increased lipophilicity of the new compounds, a fact which is proven by the superior activities of compounds 17 and 18.
The first fundamental law of toxicology is that everything is toxic - in the appropriate dose. And the corollary is also true - there is a "safe dose" (but then Tobacco Control rewrite the accepted laws of science to fit their propaganda). There are many measures of toxicity. For example, LC50 is the lethal concentration required to kill 50% of the population, where the lethal concentration would typically be expressed in milligrams per kilogram of body weight. The levels of the "toxins" in a single cigarette (and in the smoke produced by it) are miniscule and harmless. The human body is highly efficient at "flushing out" the vast majority of toxins but some toxins do have a cumulative effect over decades of ingestion.