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What are the functions of CREB?

Updated: 10/31/2022
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CREB is a transcription factor that regulates the transcription of certain genes. It is involved in many cell processes, but its role in memory formation is the most extensively studied. Specifically, CREB appears to be important for a process called long-term potentiation, a major mechanism of storing memories in the brain.

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Q: What are the functions of CREB?
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CREB is a transcription factor whose name is short for cAMP response element-binding protein. It is classically activated by the cAMP intracellular signaling cascade, in which elevated intracellular cAMP levels activate cAMP-dependent protein kinase (PKA). PKA then activates CREB by phosphorylating it on specific serine and threonine admino acid residues, changing the properties of CREB so that it can bind DNA and other proteins to regulate transcription of certain genes.


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