analgesic and antipyretic
The melting point of 4-bromoacetanilide is approximately 168-170 degrees Celsius.
Para-bromoacetanilide is used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. It is also used as a reagent in organic chemistry reactions, such as the preparation of amides and amines. Additionally, para-bromoacetanilide can be used in research studies as a model compound for studying the behavior of substituted acetanilides.
Acetanilide undergoes bromination in the ortho and para positions due to the presence of the activating amino group that directs the electrophilic bromine to these positions. In the reaction mixture, the para-bromoacetanilide is the major product compared to the ortho isomer, typically in a ratio of about 4:1.
Antipyretic and Analgesic
The Acetanilide is a benzene with a acetamido group attached to it. The acetamido group is electron donating and therefore it directs other substituents to the ortho and para positions. The acetamido group is also a very large group and the ortho position is right besides the acetamido group. This creates steric hindrance from bromine from getting to the ortho position and therefore only para-bromoacetanilide or 4-bromoacetanilide is created mainly from a bromination of acetanilide.
The melting point of 2-bromoacetanilide is significant in determining its purity and identity because it serves as a unique characteristic that can be compared to a known value. A pure substance will have a specific melting point range, and any deviation from this range can indicate impurities or a different compound. By comparing the observed melting point of 2-bromoacetanilide to the literature value, one can assess the purity and confirm the identity of the compound.
The melting point of p-bromoacetanilide is approximately 172-174°C.
In the preparation of p-bromoacetanilide, bromine is added to acetanilide in the presence of hydrochloric acid as a catalyst. The mechanism involves the electrophilic substitution of a hydrogen on the benzene ring by bromine. The hydrogen is replaced by a bromine atom to form p-bromoacetanilide.
Aniline is a benzene with an amine group attached to it. When you brominate aniline, since aniline is electron donating, it directs other substituents to the ortho and para positions. Therefore you will not only get para-bromoacetanilide. However if you just want para-bromoacetanilide, you should go through acetylation first because this changes the amine group on the aniline into an acetamido group which is very bulky and big, and also electron donating. Since it is so big, the bromine cant attach to the ortho positions because of the steric hindrance caused by the very bulky acetamido group and therefore you will get para-bromoacetanilide as your product.
Sodium sulfate is added in the preparation of para bromoacetanilide to facilitate the separation of the product from the reaction mixture. It helps in forming a complex with excess bromine and bromine water, allowing easy removal of impurities. Sodium sulfate is also used to dry the organic layer during the extraction process.
2 of the 4 pairs are actually used. However, if the connection works at 1 Gbps, then all 4 pairs are used.2 of the 4 pairs are actually used. However, if the connection works at 1 Gbps, then all 4 pairs are used.2 of the 4 pairs are actually used. However, if the connection works at 1 Gbps, then all 4 pairs are used.2 of the 4 pairs are actually used. However, if the connection works at 1 Gbps, then all 4 pairs are used.
(4 + 4/4) x 4