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They are both stating the same thing, and often can be used interchangeably. The difference is purely in the application, or use. If you are doing math calculations, you want a 'numerical' statement as in 2, in writing, often the alphabetical 'two' is better.

You can use 'two' in mathematics, but '2' is a shorthand method. Can you imagine trying to add

two Hundred twenty two + seventy two

instead of 222 + 72?

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Q: What is the difference between 2 and two?
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Two numbers that have the sum of 8 and a difference of 2?

5 + 3 =8 and 5-3 = 2 The difference between the two numbers is 2.

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The answer will depend on what two characteristics!

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