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If your using exponents, brackets and numbers with 2's as their digits; then it would have to be:

222 (squared) = 49284

This is the lowest number you can get to using four 2's and exponents.

BUT if your using operations like +, -, x, etc. then:

(2-2) + (2-2) = 0

would be more suited, as 0 is the lowest number.

You can mix and match all you want with this one, but 0 has to be your answer)

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11y ago

What else can I help you with?