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What is the glucose sensor in B-cells Why?
glucokinase. glucokinase has a high km(low affinity for glucose) so glucokinase only phosphorylates glucose when blood glucose is high, such as after a meal. As such, it makes sense that this would be sensor for B-cells
Which has a higher Vmax: glucokinase or hexokinase?
Glucokinase
Why is glucokinase inactive in the nucleus?
Glucokinase Regulatory Protein is found in the nucleus which binds glucokinase to inactive it
Differences of Hexokinase and glucokinase?
n nHexokinase: Its function is to make sure there is enough glc for the tissues, even in the presence of low blood glc concentrations, by phosphorylating all the glc concentration gradient between the blood and the intracellular environment. n nGlucokinase: Its function is to remove glc from the blood following a meal. n n(Hexokinase, Phosphofructokinase and pyruvate kinase, are 3 regulatory enzymes of glycolysis.) nLiver has an additional enzyme, glucokinase, that phosphorylate only glc n n1. Glucokinase has a high Km because it phosphorylates glc only when its concentration is high. This occurs during the brief period after consumption of a carbohydrate rich meal, when high glc are delivered by portal vein. n n2. Glucokinase has a high Vmax, allowing the liver to remove effectively this flood of glc from the portal blood. So this prevents extreme hyperglycemia after meals. n
where is glucokinase active intracellularly?
in the cytosol
How is glucokinase regulated?
Glucokinase activity is regulated primarily by the concentration of its substrate, glucose. It has a lower affinity for glucose compared to other hexokinases, allowing it to become active only when glucose levels are high. Glucokinase is also subject to allosteric regulation by molecules such as fructose-6-phosphate and mannose-6-phosphate.
What enzyme catalyze the phosphorylation of glucose after a meal?
glucokinase
What enzyme phosphorylates 90% of the glucose in the liver?
glucokinase
Which has a higher affinity for glucose: hexokinase or glucokinase?
Hexokinase
What happens if you have a glucokinase deficiency?
You can't produce insulin
Which of the following is characteristic of hexokinase (as opposed to glucokinase)?
It is not inducible by insulin
Where is glucokinase located intracellularly?
equilibriates between the nucleus and cytosol
