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Yes, according to the blood alcohol tables published by the State of California DMV. There are sources that give an opposing answer based on the fact that blood volume does not vary directly in proportion to weight. This link provides a set of charts showing the state's estimates of blood alcohol:

http://www.dmv.ca.gov/pubs/hdbk/duichart.htm

Although the charts do not go as high as 300 pounds, you can see the difference between 150 and 210 pounds are quite significant.

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Q: Would a 150 lb man get a higher blood alcohol level after drinking 6 beers than a 300 lb man?
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