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T. S. Eliot described him during this phase of his life as "a man of the world among ascetics, and an ascetic among men of the world." Pascal's ascetic lifestyle derived from a belief that it was natural and necessary for man to suffer. In 1659, Pascal fell seriously ill. During his last years, he frequently tried to reject the ministrations of his doctors, saying, "Sickness is the natural state of Christians."

In 1662, Pascal's illness became more violent, and his emotional condition had severely worsened since his sister´s death, which happened the previous year. Aware that his health was fading quickly, he sought a move to the hospital for incurable diseases, but his doctors declared that he was too unstable to be carried. In Paris on August 18, 1662, Pascal went into convulsions and received extreme unction.

He died the next morning, his last words being "May God never abandon me," and was buried in the cemetery of Saint-Étienne-du-Mont.

An autopsy performed after his death revealed grave problems with his stomach and other organs of his abdomen, along with damage to his brain. Despite the autopsy, the cause of his poor health was never precisely determined, though speculation focuses on tuberculosis, stomach cancer, or a combination of the two.The headaches which afflicted Pascal are generally attributed to his brain lesion

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