Take HIGHWAY 2 WEST from Fredericton to NEW BRUNSWICK HIGHWAY 95 TO I-95 to HOULTON, ME at EXIT 187.
Take NEW BRUNSWICK HIGHWAY 95 to I-95 in Houlton, MAINE, U.S.A. Continue on I-95 SOUTH from there all the way down to I-10 WEST in FLORIDA via I-295 SOUTH (EXIT 362B off I-95 in FLORIDA to get onto I-295 SOUTH; EXIT 21B off I-295 to get onto I-10 WEST to LAKE CITY) to bypass Jacksonville. To bypass Providence, take I-295 (EXIT 4 off I-95 in Massachusetts). To bypass New York City, take I-287 [EXIT 21 off I-95 in NEW YORK (STATE) (first exit that you will approach in New York)] via TAPPAN ZEE BRIDGE, as opposed to George Washington Bridge). To bypass Richmond, take I-295 SOUTH (EXIT 84A off I-95 in VIRGINIA).
Take I-10 WEST to I-75 SOUTH to TAMPA at EXIT 296A near Lake City.
Take I-75 SOUTH to I-275 SOUTH to TAMPA and ST. PETERSBURG at EXIT 274.
Take I-275 SOUTH to SR-60 to TAMPA INT'L AIRPORT and CLEARWATER at EXIT 39.
Take SR-60 to SR-589 TOLL NORTH; continue on SR-589 TOLL NORTH to SR-580 which is HILLSBOROUGH AVE at EXIT 4.
Turn left off the exit ramp onto Hillsborough Ave (SR-580 WEST). Take SR-580 WEST on Hillsborough Ave to Dunedin.