+25 and -2 , although it's really stretching things to use -2 for a factor of 50 .
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Take your pick out of: 23 29 31 37 41 43 and 47 because as prime numbers they have only two factors
23 or 41
46 is between 40 and 50
Prime numbers have only two factors.
The sum of the first 50 natural numbers is 1,251.