Factors of 16 are 1, 2, 4, 8, and 16.
The only prime factor is 2. Note that 1 is neither prime nor composite number.
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2 is the largest and only prime factor of 16.
The only prime factor these numbers share is 2. It is the only prime factor of 64, which is 2 to the 6th power. The hcf is 16, but that is not a prime.
If you mean 4 multiplications of 2 then they are the prime factors of 16 because 2222 is not a prime number
16 is a composite number because it has at least one positive factor other than one or itself.