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The greatest common factor of 16 and 100 is 4.

The greatest common factor is the highest number that divides exactly into two or more numbers.

16: 1, 2, 4, 8, 16

100: 1, 2, 4, 5, 10, 20, 25, 50, 100

16 factors into [2 2 2 2]

100 factors into [2 2 5 5]

common factors are [2 2], so the answer is 4.

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