Well it depends what your measuring
If its water then 1ml is equal to 1g so the answer is 500g of water in 500ml, but it depends on the density of the material, but most liquids (eg milk) are close enough to water
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A gram is a measure of mass. A millilitre is a measure of volume. The two measure different things and, according to basic principles of dimensional analysis, conversion from one to the other is not valid.
If you are not convinced, consider a 1000 mL of air. How many grams? Next consider a 1000 mL of lead. How grams?