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Although not everyone follows this naming convention, multiple regression typically refers to regression models with a single dependent variable and two or more predictor variables. In multivariate regression, by contrast, there are multiple dependent variables, and any number of predictors. Using this naming convention, some people further distinguish "multivariate multiple regression," a term which makes explicit that there are two or more dependent variables as well as two or more independent variables.

In short, multiple regression is by far the more familiar form, although logically and computationally the two forms are extremely similar.

Multivariate regression is most useful for more special problems such as compound tests of coefficients. For example, you might want to know if SAT scores have the same predictive power for a student's grades in the second semester of college as they do in the first. One option would be to run two separate simple regressions and eyeball the results to see if the coefficients look similar. But if you want a formal probability test of whether the relationship differs, you could run it instead as a multivariate regression analysis. The coefficient estimates will be the same, but you will be able to directly test for their equality or other properties of interest.

In practical terms, the way you produce a multivariate analysis using statistical software is always at least a little different from multiple regression. In some packages you can use the same commands for both but with different options; but in a number of packages you use completely different commands to obtain a multivariate analysis.

A final note is that the term "multivariate regression" is sometimes confused with nonlinear regression; in other words, the regression flavors besides Ordinary Least Squares (OLS) linear regression. Those forms are more accurately called nonlinear or generalized linear models because there is nothing distinctively "multivariate" about them in the sense described above. Some of them have commonly used multivariate forms, too, but these are often called "multinomial" regressions in the case of models for categorical dependent variables.

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Q: What is the difference between multivariate regression and multiple regression?
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