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The prefix which refers to the number 12 is dodeca-, from the Greek word for 12, Romanized as dodeka. For example, a twelve-sided polygon is called a dodecagon, and a twelve-sided polyhedron is called a dodecahedron. There is a branch of musical composition called dodecaphony, which refers to using all twelve notes of a chromatic musical scale within the piece.

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Q: What prefix means 12?
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