The weight of meat depends upon a number of factors such as its type, the manner in which it is prepared for consumption (ground or on the bone), and the moisture content.
That being said, you can't go wrong if you use the general rule of thumb that a pound of ground or cubed meat is about two cups. Therefore, two pounds of meat would equal about four cups--give or take a few ounces.
Don't worry about being exact! It's been my experience that most meat recipes turn out just fine--regardless of whether you use a little more or a little less. Use common sense (based upon what it is you are making) and your own instincts and preferences as to how much more or less you use.
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2.2 pounds of what? That is approx 1 kg, but the density of the material is going to determine the volume and therefore the number of cups.
Rephrase and resubmit.
Two pounds of WHAT . -Please be specific - there is a volume difference between all cooking goods.