The answer will depend on a mile of what? Walking, jogging, running, swimming? The question needs to be more specific.
To suggest two very improbable scenarios ...
If the people are lying down, head-to-toe, down the center of a highway,
then you'd have to expect to use something like 920 people to cover a mile
of white line.
If the people are all lying down side-by-side on the highway, with their hands
at their sides and all of their elbows on the white line, then it would have to be
more like something between 2,200 - 3,000 people per mile.
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