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What is para - hemophilia?
Parahemophilia is deficincy of coagulation factor V also known as Owren's disease, labile factor deficiency, proaccelerin deficiency.
What is the humoral coagulation system?
The humoral coagulation system refers to the protein coagulation factor component.
Why 6th coagulation factor is not mentioned about?
Factor VI is not generally included in discussions about coagulation factors because it was previously thought to be an activated form of factor V. Further research has since shown that factor VI is not a distinct factor.
Which pathway of blood coagulation has factor VIII th as important factor?
Factor VIII is crucial in the intrinsic pathway of the blood coagulation system. It helps in the activation of factor X, which is a key step in the formation of a blood clot. Without factor VIII, this pathway would be impaired, leading to difficulties in clot formation.
What factor 7?
Factor VII is one of the proteinsthat causes blood to clot in the coagulation cascade.
Factor X deficiency?
DefinitionFactor X deficiency is a disorder caused by too little of a protein called factor X in the blood. It leads to problems with blood clotting (coagulation).Alternative NamesStuart-Prower deficiencyCauses, incidence, and risk factorsWhen you bleed, the body launches a series of reactions that help the blood clot. This is called the coagulation cascade. The process involves special proteins called coagulation factors. (Factor X is a coagulation factor.) Each factor's reaction triggers the next reaction. The final product of the coagulation cascade is the blood clot. When certain coagulation factors are missing, the chain reaction does not take place normally.Factor X deficiency is often caused by a defect of the factor X gene that is passed through families. This is called inherited factor X deficiency. Bleeding ranges from mild to severe.Factor X deficiency may also develop due to another condition or use of medications. This is called aquired factor X deficiency. Acquired factor X deficiency is common. It may be caused by a lack of vitamin K, amyloidosis, severe liver disease, and use of drugs that prevent clotting (anticoagulants such as warfarin or coumadin). Some newborns are born with vitamin K deficiency. See: Vitamin k deficiency bleeding in newbornsWomen with factor X deficiency may have very heavy menstrual bleeding and bleeding after delivery. Newborn boys with the condition may have longer-than-normal bleeding after circumcision.Inherited factor X deficiency affects 1 out of every 500,000 people.SymptomsNosebleeds (epitaxis)Bleeding into jointsMusclebleedingMucous membranebleedingSigns and testsProlonged prothrombin timeProlonged partial thromboplastin timeLow factor X activityNormal thrombin timeTreatmentTreatment for the bleeding disorder involves infusions of fresh frozen plasma or factor X concentrates into the blood during sudden (acute) episodes or before surgery.Support GroupsYou can ease the stress of illness by joining a support group where members share common experiences and problems.See: Hemophilia - resourcesExpectations (prognosis)The outcome is usually good with mild disease or treatment.Inherited factor X deficiency is a life-long condition.The outlook for acquired factor X deficiency depends on the underlying cause. If it is caused by liver disease, the outcome depends on how well your liver disease is controlled. Taking vitamin K supplements will treat vitamin K deficiency. If the disorder is caused by amyloidosis, surgery is done to remove the spleen.ComplicationsSevere bleedingor sudden loss of blood (hemorrhage) can occur. The joints may get deformed in severe disease from many bleeds.Calling your health care providerCall your health care provider, go to the emergency room, or call the local emergency number (such as 911) if you have an unexplained or severe loss of blood.PreventionInherited factor X deficiency is rare. There is no known prevention.ReferencesKessler C. Hemorrhagic disorders: Coagulation factor deficiencies. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 180.Takabe K, Holman PR, Herbst KD, Glass CA, Bouvet M. Successful perioperative management of factor X deficiency associated with primary amyloidosis. J Gastrointest Surg. March 2004;8:358-362.
What are the steps of Coagulation pathway?
Blood coagulation can occur either through an intrinsic or extrinsic pathway. The first step in either pathway begins with the production of Factor X,which marks the common pathway of coagulation.
What is factor VIII deficiency?
Hemophilia
What factor initiates the coagulation cascade in vivo?
In vivo, the coagulation cascade is initiated by tissue factor (TF) which is exposed to blood following vessel injury. TF forms a complex with factor VIIa, leading to activation of Factor X and subsequent activation of thrombin, resulting in fibrin formation and clot formation.
What cause a coagulation cascade?
A coagulation cascade is caused by the tissue factor pathway. You can learn more about this online at the Wikipedia. Once on the page, type "Coagulation" into the search field at the top of the page and press enter to bring up the information.
In what general way do the intrinsic and extrinsic mechanisms of clotting differ?
extrinsic pathway of coagulation the mechanism that produces fibrin following tissue injury, beginning with formation of an activated complex between tissue factor and factor VII and leading to activation of factor X, inducing the reactions of the common pathway of coagulation.intrinsic pathway of coagulation a sequence of reactions leading to fibrin formation, beginning with the contact activation of factor XII, and resulting in the activation of factor X to initiate the common pathway of coagulation.
What is fibrinogen factor?
Fibrinogen (factor I) is a soluble plasma glycoprotein, synthesized by the liver, that is converted by thrombin into fibrin during blood coagulation.
