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The answer depends on the density/volume of the substance being measured.

If the substance is water, or the same density as water:

1 ml of water = 1 gram, therefore -

0.5ml of water = 0.5 grams = 500 mg

the best way to measure 500mg of something would be to use small scales, accurate to at least 0.1 of a gram.

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Q: 500 mg measured in a 3 ml syringes?
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