They measur the miles of highway in use. Starting from the west at one mile amd from the south at one mile. SO if you were traveling from the western or southern border of your state you would know exactly how many miles you had come.
Added: The mile markers also PRIMARILY identify the location on the Interstates so that emergency and service vehicles can identify where they are. The intersections are few and usually far between and there are no intersection roads, so being able to pinpoint the location of an incident becomes of prime importance.
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