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no, a 44magnum round generates way too much pressure to be fired in a 410 chamber if your guns full choke as most 410's are it will in some cases spilt or bulge the barrel, 410 slugs are more powerfull then a 357 magnum, and theres no real gain in power lobbing a 44 mag out a smooth bore

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Q: Are 410 shotgun rounds and 44 mag rounds interchangable?
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