If you mean 2/72, yes it can be simplified or reduced further. Divide both the numerator and the denominator by 2, and it yields a result of 1/36. It cannot be reduced further than that while remaining a common fraction.
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Simplified.. 48/72 = 2/3
72 is an integer so the simplified fraction is 72/1
The answer is 3 over 2
27/72 simplified is 5/18
-13/72 cannot be simplified.