Can E equals mc2 be proved wrong?

Answer 1

Yes, it could easily be proven wrong by observing the transitions between mass and energy

in high-energy particle accelerators, and measuring the beginning and ending quantities of

mass and energy.

This has been done thousands of times in the past 60 or 70 years, and the observed numbers

always confirm it.

Pretty neat, when you consider that [ E = m c2 ] was derived on purely theoretical grounds

a long time before it ever became possible to check it in the real world, and when the machinery

was invented that could check it, it was proven correct.