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I guess it can. I'm not a doctor and I'm not giving a scientific answer, it's just that everytime I use Minoxidil 5% I have a lot of arrythimas, I feel like my heart skips a beat and jumps many times a day. And when I stop using it they stop too. So I'm pretty sure it can.

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Q: Can Minoxidil 5 percent cause an arrhythmia?
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