It should be able to as long as it is in a cage or familiar environment. Make sure it is somewhere secure that won't slide around, rock back and forth or be too jarring. If it shows signs of getting stressed/aggravated, you may want to pull over along the way and help it calm down.
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About 2/3 Hours. (:
195 km
Did you read your question before posting it? Apart from the fact that few cars can travel at 350 miles per hour, the question asks how much time ...[for] ... 3 hours. The answer, obviously, is 3 hours!
195 km
40 mph