With numbers and acronyms, use an apostrophe s. When in doubt, you can always spell it out.
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466 to the nearest hundreds is 500
There are 1000 100s in 100,000
15 hundreds = 1500
0.7 hundreds = 70 3.69 hundreds = 369
4,500 Think about it like this: 45 "100s," or 45 x 100.