That's going to depend on exactly what you want to 'do' to it.
If you think you might like to solve it for 'x', then try this:
16 + 8 + 3x + 4 = -6x - 5x
Combine the numbers on the left side:
28 + 3x = -6x -5x
Combine the 'x' terms on the right side:
28 + 3x = -11x
Subtract 3x from each side:
28 = -14x
Divide each side by -14:
-2 = x
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