81 = 3 x 27 = 3 x 3 x 9 = 3 x 3 x 3 x 3
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As a product of its prime factors: 2*61 = 122
As a product of its prime factors in exponents: 2^3 times 5^2 = 200
48 = 2 × 2 × 2 × 2 × 3
Both of these:52 = 2 x 2 x 1352 = 22 x 13
Since the greatest 1-digit number is 9, the answer is 9 x 9 = 81.