You can't if its just adding and subtracting. If you can multiply and divide then:
9 * 8 = 72
5 * 6 = 30
30 + 72 = 102
102 - 3 = 99
Notice I haven't used all of the numbers... I don't know whether you were supposed to...
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No. Adding negative numbers will make them more negative.
For example, by adding 1 + 1 + 1 ... (a total of 100 times).
By adding an odd number with an even number.
(1 + 5 - 3) * 8 = 24
The numbers needed adding are 11 and 11 respectively because 16/48 = 1/3