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You need a very sensitive scale to measure 4mg reliably and consistently.

If possible you could make a homogeneous mixture with some inert ingredient and get a larger sample to weigh, making errors less pronounced. I.e. you could mix 1 gram into 999 grams of inert stuff, then measure 400 milligrams of the mixture to get 4 mg of the desired substance.

(dilution in a liquid is another means of accomplishing the same thing).

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Q: How do you measure out 4 mg?
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