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Depends what you're asking. If all 4 letters have to be involved, that's very different than if you can have combos of 3,2, or 1. Also if they have to make a word then that's a different question that should be posed in the English category. If however, it is merely how many 4 letter combinations can you make of those 4 letters, then it is 24. Found by 4! which is merely 4x3x2x1.

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13y ago

What else can I help you with?