This would be 26 x 26 x 10 x 10 = 67,600. Provided repetition is allowed.
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There are 26 possible letters and 10 possible numbers. The number of license plates possible is then 26*26*10*10*10*10 = 6760000.
11,232,000
(26) x (26) x (10,000) = 6,760,000
If it alternates and you start with a letter, then there are 11,232,000 permutations. Then if you start with a number and alternate, there are another 11,232,000 permutations, for a total of 22,464,000 permutations. If you exclude the letters I, S, B, and O (because they look kind-of like 1, 5, 8, & 0 - kind-of important on license plates) then you are down to 6,652,800 & 13,305,600 respectively.
456,976,000