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The number of combinations for selecting 6 numbers from a set of 59 can be calculated using the formula for combinations, which is ( C(n, k) = \frac{n!}{k!(n-k)!} ). For this case, ( n = 59 ) and ( k = 6 ), resulting in ( C(59, 6) = \frac{59!}{6!(59-6)!} = 45,379,620 ). Therefore, there are 45,379,620 different combinations of 6 numbers that can be chosen from the numbers 1 to 59.

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