2x^2+3xy-4y
2(4)+3(2)(-4)-(4)(-4)
8-24+16=0
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It would help if the expression was given!
Depends what the expression is. Just plug in 8 for y in the expression and that'll do it for you.
The = sign
You don't, unless you know either the value of x or what the expression equals.
The answer is -369.