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The word 'denominator' refers to the bottom number of a fraction. For example, 7 is the denominator of the fraction 3/7. As 16 and 25 are not fractions then there is no denominator of any kind.

If the question refers to the Least (or Lowest) Common Multiple (LCM), then determine the prime factors of both numbers.

16 = 2 x 2 x 2 x 2 = 24

25 = 5 x 5 = 52

The LCM is the product of the highest power of each prime factor.

The LCM of 16 and 25 is therefore 24 x 52 = 16 x 25 = 400

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Q: Least common denominator of 16 and 25?
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