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There are different World Health Organization classifications for lupus nephritis. A kidney biopsy is required to determine which classification and which level of disease activity. Different classifications respond to different treatments. The goals of treatment in lupus, including lupus nephritis, are to reduce the symptoms such as inflammation and to prevent permanent or increased damage. This goal is accomplished through the use of immunosuppressive medications. In addition to prednisone and plaquenil (hydroxychloroquine), chemotherapies and biologics are also used. Since there are different classifications of lupus nephritis, and since the classification may change in an individual over time, and since each patient responds differently to these medications, there is no one answer.

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