The correct way to write the sentence is "two and two makes four."
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Makes 2 + 2 makes 4
Two and two make four. Makes is for a singular subject, make is for a plural subject. When in doubt, try substituting the two twos with other words, like "leaves and grass turn brown in fall." You wouldn't use "turns" in that sentence, which is structured like the original sentence.
Depends whether you're a Yank or British.
Two and two makes four because when you add the quantity of two to another quantity of two, you end up with a total of four. This is a fundamental principle in arithmetic known as addition, where combining equal quantities yields a sum that corresponds to their total.
The word make means "amount to". Therefore it would be 'one and one make two and two and two amount to four'. Now if you wanted to properly use the makes you would use it like this. John makes wooden toys for needy children. I make the pretty designs for the wooden toys. Sherry makes the gift boxes and pretty note cards for the child to receive the wooden toy. All together we made 700 toys this year. It takes us 12 months to make that many. So our total output of 700 make it 58.33 toys a month. Do you see the difference? Third person uses makes. First person uses make. Totally something uses make. Plural of people uses made. * * * * * The above discussion begs the question as to whether it is "amount to" or "amounts to". I go for the latter!