Assuming the question is about speeds, there is no simple answer.
For example, a speed that is safe for a car on a winding road in wet weather would not be safe for an aircraft - the aircraft would probably stall!
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Secure is a synonym for safe.
No. Safest is the superlative form of the adjective safe (most safe).The adverb form of safe is safely, and the superlative form of the adverb is most safely.
The word safe has one syllable.
The word safe has one syllable.
was safe and well tolerated in this patient population for the 52 weeks of the study