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In a tetrahedral molecule eg methane (CH4), hybridisation occurs between the 2s orbital and three p orbitals to form four sp3 hybrid orbitals. See: http://www.chem1.com/acad/webtext/chembond/cb06.html and: http://www.mikeblaber.org/oldwine/chm1045/notes/Geometry/Hybrid/Geom05.htm

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