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If you know nothing about the parents' risk for these diseases or other contributing factors (race, environment, etc.), then the answer depends solely on the probabilities of getting any one of those diseases.
Let's say the risks are P1, P2 and P3 where P1 is the probability of the baby having rare disease #1 and so on. A probability of 1 is a sure thing and 0 means no chance, so the probability of a rare disease is a number slightly greater than 0.
The risk of getting disease #1 AND #2 AND #3 is the product: P1xP2xP3.
If, for example, the each risk is one in a million (P1=P2=P3=0.000001), then the odds of having a baby with all three is 1 in 1,000,000,000,000,000,000.
The math changes severely if one of the parents is at risk for the disease. Let's say the mother has one gene that causes the disease #1. Then P1 is no longer 1 in a million, it is 0.5. If the parent's racial group is afflicted with P2=0.001 as well, then P=0.5x0.001x0.000001=0.000000005, which is 500,000 the risk of others.
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How rare is a hole in one?
Approximate odds are 8200 to 1 on a average length par three hole tee.
What is the meaning of beat the odds?
This is one of those really weird English sayings. I'm going to go out on a limb and claim that no one, ever, under any circumstances, "beats" the odds. Whatever we do, or whatever happens to us, the event is associated with some probability on some level. We may do many things to affect or change the probabilities, ranging from out-and-out cheating to all kinds of legitimate steps to improve the odds, but whatever happens next can be analyzed in terms of the actual remaining probabilities. If I have manipulated a situation in such a way that an outcome is certain, then I haven't "beaten" the odds, I have taken action to see that the odds are "one in one". If a rare event occurs, (winning a lottery), I haven't "beaten the odds", it's simply a matter of events unfolding as they did. Or.. It could mean:
What is the meaning of beat the odd?
This is one of those really weird English sayings. I'm going to go out on a limb and claim that no one, ever, under any circumstances, "beats" the odds. Whatever we do, or whatever happens to us, the event is associated with some probability on some level. We may do many things to affect or change the probabilities, ranging from out-and-out cheating to all kinds of legitimate steps to improve the odds, but whatever happens next can be analyzed in terms of the actual remaining probabilities. If I have manipulated a situation in such a way that an outcome is certain, then I haven't "beaten" the odds, I have taken action to see that the odds are "one in one". If a rare event occurs, (winning a lottery), I haven't "beaten the odds", it's simply a matter of events unfolding as they did. Or.. It could mean:
What are the odds of sinking 8 ball on the break twice in a row?
The odds of sinking the 8 ball on the break in a standard game of pool are typically around 1 in 40. To calculate the odds of sinking it twice in a row, you would multiply the probability of sinking it once (1/40) by itself, resulting in a probability of approximately 1 in 1,600. This means that the chances of sinking the 8 ball on the break twice in a row are quite low.
What are the differences between probability and coincidence?
The difference between probability and coincidence are that probability means the odds or how likely some thing will happen or not. While coincidence means something that did happen already, and the likely hood of what caused this to happen either being rare or common.
