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In the United States approximately 1 in 500 to 1 in 1000 male live births are affected with the syndrome. See the link. (my endrocronologist - who has been in practice 35+ years has never seen another klinefleters patient and we live in Boston. Many people who have it - that never desire children may never be diagnosed. therefore I think the number is closer to the one in a 1000
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