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What is a bicelle?

Bobo192 ∙

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∙ 9y ago

Updated: 11/1/2022

A bicelle is a self-assembled aggregate of phospholipid in water, which combines flat bilayer-like and curved micelle-like features.

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∙ 9y ago

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What technologies can solve the problem of membrane protein crystallization?

One great strategy to tackle difficulties in membrane protein crystallization is our bicelle-protein crystallization technique. Bicelles are small bilayer disks formed in lipid/amphiphile mixtures, into which membrane proteins can be incorporated. At low temperature, bicelle-forming lipid/amphiphile mixtures are not viscous, but they tend to develop a gel-like consistency at higher temperatures. Thus, with bicelle forming lipid/amphiphile mixtures it is possible to access a variety of lipid bilayer structures simply by varying temperature.

What is a bicelle?

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What technologies can solve the problem of membrane protein crystallization?

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