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In chemistry a convergent synthesis is a strategy that aims to improve the efficiency of multi-step chemical synthesis. In linear synthesis the overall yield quickly drops with each reaction step: A → B → C → D Suppose the yield is 50% for each reaction, the overall yield of D is only 12.5% from A. In a convergent synthesis A → B (50%) C → D (50%) B + D → E (25%) the overall yield of E (25%) looks much better. Convergent synthesis is applied in the total synthesis of complex molecules and involve fragment coupling and independent synthesis. Example:

  • Convergent synthesis is encountered in dendrimer synthesis where branches (with the number of generations preset) are connected to the central core
  • Proteins of up to 300 amino acids are produced by a convergent approach using chemical ligation.
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Q: What is a convergent synthetic approach?
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