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Durule's principle of insoluble matrix refers to the concept in materials science and solid-state chemistry that suggests that certain compounds can remain stable in an insoluble matrix. This principle implies that when a compound is embedded in an insoluble host material, its solubility and reactivity can be significantly reduced. This characteristic is important in various applications, such as in the formulation of pharmaceuticals or the development of composite materials, as it helps in controlling the release and stability of active ingredients.

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